Skip to content
August 7, 2025
  • Facebook
  • Twitter
  • Instagram
  • Youtube
  • tiktok
MILLENNIUM NEWS 24/7

MILLENNIUM NEWS 24/7

Bridging The Community’s World Wide

  • Home
  • IP TV LIVE
  • PODCAST
  • U.S.News
  • LOCAL ELECTION
  • State News
    • Alabama
    • Alaska
    • Arizona
    • Arkansas
    • California
    • Colorado
    • Connecticut
    • Delaware
    • Florida
    • Georgia
    • Hawaii
    • Idaho
    • Illinois
    • Indiana
    • Iowa
    • Kansas
    • Kentucky
    • Louisiana
    • Maryland
    • Massachusetts
    • Michigan
    • Maine
    • Minnesota
    • Mississippi
    • Missouri
    • Montana
    • Nebraska
    • Nevada
    • New Hampshire
    • New Jersey
    • New Mexico
    • New York
    • North Carolina
    • North Dakota
    • Oregon
    • Pennsylvania
    • Rhode Island
    • South Carolina
    • South Dakota
    • Tennessee
    • Texas
    • Virginia
    • Washington
    • West Virginia
    • U.S. Virgin Islands
  • Politics
  • World News
  • Sports
  • Entertainment
  • Weather
  • Business
  • Health News
  • ADVERTISEMENT
  • About Us
  • Contact us
Live TV

Higher-dose naloxone spray didn’t save more lives, researchers find

NEW YORK— A new, higher-dose nasal spray for reversing opioid overdoses did not save more lives than the previous standard dose, but it did cause more vomiting and other side effects, researchers wrote in a study published Thursday.

The 8-milligram naloxone spray — twice as potent as the highest dose previously available — was approved two years ago after pressure from experts and patient advocates who noted lower-dose antidotes often were being given multiple times to people suffering overdoses.

The new study, which was limited to more rural parts of New York state, is being called the first to provide real-world data on the differences between the two sprays. The paper was published by the Centers for Disease Control and Prevention, but the federal health agency was not involved in the research.

The higher-dose “did not provide added benefit,” the authors wrote.

“What was really remarkable was the survival was the same, but the amount of withdrawal symptoms was significantly larger in the people that got the 8-milligram dose,” said one of the authors, Dr. Michael Dailey of Albany Medical College.

Dailey said the study did not lead him to endorse one product over another. But, he said, “its important for us to recognize that the potential for increased side effects is real.”

The researchers worked with the New York State Police, who respond to emergencies along highways and in rural areas.

Three troops in eastern New York were given 8-milligram sprays. Eight troops based further away from Albany were stocked with 4-milligram doses. The study results were based on 354 instances in which troopers administered naloxone sprays from late March 2022 to mid-August 2023.

In cases where overdose patients were still alive when troopers arrived, 99% survived after getting naloxone, no matter which dose was given.

People who got 4-milligram sprays usually got more than one dose — 1.67 doses on average, equivalent to 6.7 milligrams. But so too did those treated with the 8-milligram sprays, who got 1.58 doses, or 12.6 milligrams, on average.

In both groups, disorientation and lethargy were common when people came to.

But other problems were significantly more common in the patients who got the higher-dose sprays. About 38% experienced signs and symptoms of withdrawal, including vomiting, abdominal pain, sweating, shaking and diarrhea. Only 19% of those getting the lower dose had those problems, the study found.

That’s a concern because it could actually contribute to future overdose deaths, said Dr. Alexander Walley, a Boston Medical Center addiction specialist who also works with the Massachusetts health department.

If someone has extra withdrawal symptoms when they are rescued from an overdose, they may remember the pain and discomfort of that experience and — experts fear — might actually avoid having someone with naloxone around when they take drugs in the future, Walley said.

The study is limited and imperfect in how it randomized who got which doses, Walley said, but it’s nevertheless “good quality evidence.”

“The solution to a more potent (illicit) drug supply is not necessarily a more potent naloxone,” he said. “It’s having people be witnessed when they use the drugs, and have that witness be someone who can administer naloxone and call for help.”

About Author

Habib Habib

See author's posts

Continue Reading

Previous: Could a storm like the Blizzard of ’78 happen again in Massachusetts?
Next: Inflation is nearly back to 2%. So why isn’t the Federal Reserve ready to cut rates?

Related Stories

Lady Gaga leads 2025 MTV Video Music Awards nominations, followed by Bruno Mars and Kendrick Lamar

Lady Gaga leads 2025 MTV Video Music Awards nominations, followed by Bruno Mars and Kendrick Lamar

The Justice Department seeks voter and election information from at least 19 states

The Justice Department seeks voter and election information from at least 19 states

Jeannie Seely, soulful country singer behind hits like ‘Don’t Touch Me,’ dies at 85

Jeannie Seely, soulful country singer behind hits like ‘Don’t Touch Me,’ dies at 85

Entertainment

Emmylou Harris and Brad Paisley are headed for Nashville Songwriters Hall of Fame 1

Emmylou Harris and Brad Paisley are headed for Nashville Songwriters Hall of Fame

Eddie Palmieri, pioneering Latin jazz musician and Grammy winner, dies at 88 2

Eddie Palmieri, pioneering Latin jazz musician and Grammy winner, dies at 88

Lady Gaga leads 2025 MTV Video Music Awards nominations, followed by Bruno Mars and Kendrick Lamar 3

Lady Gaga leads 2025 MTV Video Music Awards nominations, followed by Bruno Mars and Kendrick Lamar

Ozzy Osbourne died of a heart attack, report says, citing death certificate 4

Ozzy Osbourne died of a heart attack, report says, citing death certificate

Flaco Jimenez, Texas accordionist who expanded popularity of conjunto and Tejano music, dies at 86 5

Flaco Jimenez, Texas accordionist who expanded popularity of conjunto and Tejano music, dies at 86

Jeannie Seely, soulful country singer behind hits like ‘Don’t Touch Me,’ dies at 85 6

Jeannie Seely, soulful country singer behind hits like ‘Don’t Touch Me,’ dies at 85

Justin Timberlake says he’s been diagnosed with Lyme disease 7

Justin Timberlake says he’s been diagnosed with Lyme disease

Top News

Emmylou Harris and Brad Paisley are headed for Nashville Songwriters Hall of Fame

Emmylou Harris and Brad Paisley are headed for Nashville Songwriters Hall of Fame

Eddie Palmieri, pioneering Latin jazz musician and Grammy winner, dies at 88

Eddie Palmieri, pioneering Latin jazz musician and Grammy winner, dies at 88

Trump could meet in person with Putin as soon as next week, White House official says

Trump could meet in person with Putin as soon as next week, White House official says

Trump to put additional 25% import taxes on India, bringing combined tariffs to 50%

Trump to put additional 25% import taxes on India, bringing combined tariffs to 50%

  • Home
  • About Us
  • Facebook
  • Twitter
  • Instagram
  • Youtube
  • tiktok
Editor: Nur M Tofader, Home Office: 250 Park Avenue, 7th Floor, New York, NY 10177 Tell: 718 893 0002 (Office), 7188441300, +1212 401 6266, e-mail: Info@millenniuamtv24.com, e-mail: Info@millenniuamnews24.com, Copyright © Millennium News 24/7 | DarkNews by AF themes.